3/21/2024 0 Comments Pbp3 class b![]() pbp1a pbp2a double mutants are not viable.12,11 Both class B. ![]() All other funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. exposed domains.7 Finally, PBP3 (DacA) is a class C, low- molecular weight (LMW) PBP with. pneumoniae, performing critical roles in septal and. ![]() The two class B PBPs (PBP2x and PBP2b) are individually essential in S. In addition, PBP2x possesses a C-terminal ex-tension consisting of two PASTA (PBP- and serine/threonine kinase-associated)domains(Fig.1),eachcontainingone -he-lix and three -strands (8, 9). The specific role of this author is articulated in the ‘author contributions’ section. one class C PBP (PBP3) with D,D-carboxypeptidase activity (Fig. Sanofi-Aventis provided support in the form of salary for author JD, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Jacques Dumas is employed by Sanofi-Aventis. FK is research associates of the FRS-FNRS, Belgium. is recipient of a FRIA (Fonds de la Recherche pour l’Industrie et l’Agriculture) fellowship (F.R.S.-FNRS, Brussels, Belgium). P6/19), the Fonds de la Recherche Scientifique, (IISN 4.4505.09, IISN 4.4509.11, FRFC 2.4511.06F), the University of Liège (Fonds spéciaux, Crédit classique, C-06/19 and C-09/75), and a return grant to AD. This work was supported in part by the Belgian Program on Interuniversity Poles of Attraction initiated by the Belgian State, Prime Minister’s Office, Science Policy programming (IAP no. ![]()
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